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Plasma tca concentrations may need to be monitored, and the dose of tca may need to be reduced, if a tca is coadministered with paroxetine tablets see precautions , drugs metabolized by cytochrome cyp2d6 .

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methods pooled data were analyzed from four randomized, double-blind, placebo-controlled studies that compared duloxetine at the dose range approved in japan 40 60 mg day with other ssris paroxetine 20 mg day or escitalopram 10 mg day and placebo in patients with major depressive disorder.

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paroxetine major because of the potential risk and severity of serotonin syndrome, use caution when administering ondansetron with other drugs that have serotonergic properties such as paroxetine.

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